Miami defeated Florida State 28-22 in Week 6 to cover the 3.5-point spread. The Hurricanes dominated the third quarter, scoring 14 points to pull away after Florida State mounted a fourth-quarter comeback attempt.

Miami's offense was led by Carson Beck, who connected with receivers Malachi Toney and CJ Daniels for multiple touchdown passes throughout the game. Jordan Lyle led Miami's receiving corps with 9 catches. Florida State's Thomas Castellanos was the game's leading passer with 272 yards and added 57 rushing yards, but threw an interception in the third quarter that resulted in a touchback.

The game featured two lead changes and significant momentum swings. Miami built a 21-3 halftime lead but Florida State stormed back in the fourth quarter, scoring 19 unanswered points to make the final result competitive. However, Miami's second-half dominance proved decisive. The final score fell under the 54.5 over-under line, with the game totaling 50 points.