Duke defeated Wake Forest 49-32 in Week 14, with the Blue Devils controlling most of the game behind a balanced offensive attack. Duke's defense forced multiple turnovers, including two fumbles from Wake Forest's D. Claiborne that proved costly in critical moments.

Wake Forest's Robby Ashford led the passing game with 342 yards, while Carlos Hernandez hauled in 93 receiving yards for the Demon Deacons. Despite these efforts, Wake Forest couldn't overcome Duke's consistent scoring, which included touchdowns in every quarter except the second.

Duke's Nate Sheppard contributed 75 rushing yards as part of the Blue Devils' ground game. The game exceeded the over-under of 54 points, with the final total of 81 points satisfying over bettors. Duke covered the 2.5-point spread, improving to a convincing home victory.

The second quarter proved decisive for Duke, with a critical turnover on Wake Forest's fumble play in that period setting the tone for the remainder of the game. Duke's fourth-quarter dominance sealed the comfortable margin of victory.